Tuberculosis
5 videos · updated daily
11:14 endTB Trial: Results in Key Patient Subgroups
Maelenn Gouillou of Epicentre-MSF presents endTB trial results in key subgroups of patients with drug-resistant tuberculosis, including HIV-positive patients, low BMI, diabetes and severe disease.
7:32 The STREAM Trial in Multidrug-Resistant Tuberculosis
The Union presents STREAM, a multi-country randomised trial run with the MRC Clinical Trials Unit at UCL testing shortened MDR-TB regimens; preliminary results in November 2017 put the nine-month regimen close to the 20-24 month regimen.
11:26 SHINE: Shorter TB Treatment for Children
UCL's Innovative Clinical Trials Unit presents SHINE, a multi-country randomised trial of shorter TB treatment for children coordinated by MRC CTU at UCL and published in NEJM, which led to WHO guideline changes, with a discussion on implementing its results.
1:08:18 Shorter Regimens for Drug-Resistant TB: The Trials
The Union reviews phase III trials of shorter drug-resistant TB regimens, including STREAM II, TB-PRACTECAL and BEAT-TB, as of March 2023, when several had recently reported or were about to report results.
31:42 STREAM Stage 2 Results in Multidrug-Resistant TB
Andrew Nunn, Senior Scientist and Professor of Epidemiology at the MRC Clinical Trials Unit at UCL, reviews the STREAM stage 2 trial in multidrug-resistant TB, ending on whether an effective MDR regimen should treat drug-sensitive disease.