Immunology & Inflammation
21 videos · last 6 months shuffled daily, then older videos newest first
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1:22:40 Beyond Outcomes Podcast E1: How One Founder Turned a Personal Disease Into a Medical Device Company
Jan Elsner, founder of Skinuvita, on building a device that brings medically supervised phototherapy into patients' homes, and how his own psoriasis shaped it.
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40:29 Panteli Theocharous on Autoimmune CAR T and Trial Endpoints
Dr. Panteli Theocharous discusses the benefit-risk calculus of autoimmune CAR T compared with oncology, patient burden from conditioning, apheresis and monitoring, and rethinking trial endpoints, on Life Science Connect's Cell & Gene: The Podcast.
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58:09 Imaging Endpoints in Autoimmune Disease Trials
Image Analysis Group with Profs. Mikael Boesen and Francesco Del Galdo on how MRI and quantitative imaging are used for patient stratification and efficacy endpoints in myositis, scleroderma and inflammatory arthritis trials.
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51:04 Ethical and Strategic Challenges of CAR-T Commercialisation
In a Consilium Scientific seminar, Stephany Saarti examines the strategic, operational and ethical challenges of advanced immuno-oncology therapies such as CAR-T, from evidence generation to reimbursement and access, and introduces the VERITAS framework.
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1:01:27 Evidence Beyond FEV1 for Respiratory Biologics
A Lindus Health panel discusses designing Phase 3b, Phase 4 and prospective real-world evidence studies for asthma and COPD biologics that meet payor and HTA needs, including remote spirometry and digital biomarkers.
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1:00:00 Respiratory Drug Development: Comprehensive Strategies to Improve Data Quality
A Clario webinar on strategies to improve data quality in respiratory drug development trials.
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25:23 The Stenova Trial: A New Treatment Option with Ontunisertib in Fibrostenosing CD
Florian Rieder of Cleveland Clinic, principal investigator of the Stenova trial, on ontunisertib — an oral, gut-restricted ALK-5 inhibitor — in fibrostenosing Crohn's disease.
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1:17 REPLENISH: Secukinumab in Polymyalgia Rheumatica
NEJM Group and Dr. Glaucomflecken summarise the REPLENISH trial, which evaluated the efficacy and safety of secukinumab as an alternative to glucocorticoids for polymyalgia rheumatica.
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1:14 Removing Barriers: How Clinical Trial Sponsors Support Patients
Dr. Erin Forster, director of MUSC Health's Inflammatory Bowel Disease Center, on how trial sponsors can make taking part in research easier for patients.
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2:10 The Missing Piece in IBD Treatment? Regenerating the Gut's Protective Barrier Shows Promise
Researchers at Calibr-Skaggs on CLF065, a potential first-in-class regenerative medicine designed to restore the epithelial barrier in inflammatory bowel disease.
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58:55 Using External Data in RCTs Without Introducing Bias
Unlearn founder Charles Fisher describes using existing data and predicted placebo outcomes in randomised controlled trials to run smaller trials while keeping control of bias.
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30:56 Repurposed Drugs in Progressive MS Research
Ellen Mowry, Wee Yong and Laura Airas discuss International Progressive MS Alliance projects repurposing existing drugs: GLP-1 receptor agonists, salbutamol with ibudilast, and a hydroxychloroquine trial, for the MS International Federation.
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50:54 REGENCY: Obinutuzumab in Lupus Nephritis
Brad Rovin, MD, of Ohio State University Wexner Medical Center and Ana Malvar, MD, of Hospital Fernandez in Buenos Aires present the background and central results of the phase 3 REGENCY study of obinutuzumab in active lupus nephritis, for MARKUS at HOMe.
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2:51 Digital Tools Make an Asthma Clinical Trial Easier for One Patient
A patient participating in asthma clinical trials used a day digital medical journal as part of the trial and the patient discusses the tool in this video from Astra Zeneca.
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22:10 Crohn's & Colitis Foundation on Recruiting Patients for IBD Trials
Gastroenterologist Chung Sang Tse and the Crohn's & Colitis Foundation discuss how the ADEPT trial recruited adults with inflammatory bowel disease, and which recruitment methods actually worked.
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3:24 VP of Clinical Operations on hLAB - Industry Leader in Virology & Immunology
hVIVO on hLAB, its virology, immunology and molecular laboratory services for drug and vaccine research.
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3:17 A-TAP Ankylosing Spondylitis Clinical Trials Highlights from NDORMS
A look at a Phase 2 Clinical Trial for ankylosing Spondylitis along with an interview with a study participant.
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4:32 Innovations in Immunology: The Role of VAV1 and MGDs
Monte Rosa Therapeutics on the role of VAV1 in immunology and inflammation, and its approach to targeting a protein previously considered undruggable.
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15:45 CISCRP Discusses Clinical Trials Focusing on the Patient's Point of View
Clinical Trials vendor Curebase discusses modernization in clinical trials and then interviews a Lupus clinical trials participant who discusses her experiences about the trial including informed consent and travel.
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16:28 IQVIA Looks at AI and Machine Learning in Finding Patients for Clinical Trials
This video from CRO IQVIA looks at the way AI and machine learning may aid in finding those patients and connecting them to physicians along with IQVIA's approach to AI and Machine Learning including use cases in Asthma and Ultra Rare Disease.
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2:20 Peanut Allergy Clinical Trials
A clinical trial involving immunotherapy and immunotherapy plus a probiotic for peanut allergies is explored in this video.