Data Monitoring Committees
8 videos · last 6 months shuffled daily, then older videos newest first
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1:32 Understanding Adaptive Trials
Advarra on adaptive trial designs, and how planned interim analyses let a study be modified while it is still running rather than after it completes.
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1:00:32 Charting the Content of Data Monitoring Committee Charters for Clinical Trials
The Australian Clinical Trials Alliance on what data monitoring committee charters actually contain, and the role DMCs play in the ethical conduct of clinical trials.
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45:40 The CHIPS Trial: Bayesian Adaptive Trial in JAMA
CHIPS trial co-authors Dr. Roger Lewis, Dr. Anna McGlothlin and Dr. Nick Berry discuss on Berry Consultants' In the Interim podcast the Bayesian adaptive design that found cold-stored platelets non-inferior out to 21 days.
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2:36 Addressing Operational Challenges in Adaptive Oncology Trials
Advarra on why adaptive trials depend on real-time data quality, and what that asks of Data Monitoring Committees and biostatistical teams at each interim analysis.
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1:01:08 Adaptive Allies: The Evolving Roles of DSMBs and Investigators in Bayesian Platform Trials
The Australian Clinical Trials Alliance on how Bayesian adaptive designs change the job of a Data Safety Monitoring Board, and the governance needed to protect trial integrity.
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1:55 DSMB (Data Safety Monitoring Board) Worked in AstraZeneca Study
A video by the CBS news affiliate in Tampa Bay Florida looks at the importance of the clinical trial Data Safety Monitoring Board.
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5:36 NEJM Evidence on How Interim Analyses Work
A Stats, STAT! animated video from NEJM Evidence explores interim analyses in clinical trials, in which researchers may assess safety, efficacy and sample size assumptions, and why they require careful planning.
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41:25 Implementing Adaptive Trials
Dr. Anna McGlothlin and Dr. Michelle Detry of Berry Consultants on implementing adaptive clinical trials, and the statistical work their team does behind them.